Science is the best way to dig out the truth of the natural world, but that doesn’t prevent many people from denying truths that are inconvenient or contrary to their preconceptions or faith.

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U.S. 30, east of Blair, Neb. June, 2011, Iowa DOT

The stunning floods, tornadoes, droughts and heat waves in 2011 caused more Americans to accept global warming — even if climate whizzes are chary of attributing individual weather events to the warming trend.

In the last month, denial of global warming has subsided in the wake of a string of floods, droughts and heat waves, culminating in the “summer in March,” 2012. Although Americans’ attitudes toward warming ebb and flow, on April 17, a Yale University poll reported that 69 percent think global warming is affecting the weather in the United States.

In the same month, however, a Discovery Channel series called “Frozen Planet” attracted ire when scientists noted that it documented massive melting at the poles, but ignored the “why?” question. Scientists have said for decades that polar warming would be an early sign of global warming.

In the recent past, this phenomenon of “denialism” has also appeared in doubts about issues that have long been settled in the scientific community, such as whether:

An April conference at the University of Wisconsin-Madison delved into the origin and development of denialism. Is a refusal to face facts growing more common? Are there better ways to explain how the world works?

Denial in the brain

Scientists, by training, are professional skeptics, but if after decades of debate 97 percent of them accept the link between greenhouse gases and global warming, why are so many unconvinced? “The theory is that if we tell people what we know, they will change,” says Arthur Lupia, a professor of political science at the University of Michigan, but that ignores how people really listen and make decisions.

Speaking to a high-level gathering of science journalists in Madison, Lupia said the problem does not reside with the audience. “The problem is us. Our expectations aren’t consistent with how humans react to information, what they will listen to, or what they will remember. People don’t pay attention, or they don’t remember what we said or what we intend them to remember.”

To change an opinion, you must first attract and then hold the audience’s attention, but attention wanders all the time. No matter how important you think your message is, Lupia says, “Biology does not change its rules … about when people will think about things that challenge them. … If I am saying something abstract, that does not connect to your core aspirations,” you may be more interested in counting tiles on the ceiling.

Can you hear me now?

To communicate with a general audience, Lupia says, “You have to make it close, concrete, immediate. I understand the joy of telling the whole story about climate, but there are some audiences that can’t handle it; in their reality, it’s not the most immediate thing. They might be more receptive if you make the conversation about pollution, energy security or energy costs.”

Information is filtered by attention and ideology, Lupia concludes. “Learning is always an away game. All the real action occurs in the audience’s heads,” he says.

Reasoning: Logical or “motivated”?

Ideally, science adheres to logical reasoning: the conclusion must be true if the premises are true.

But psychologists say it’s common to see “motivated reasoning,” the tendency to fit new information into existing attitudes.

Making a judgment or decision can often involve a “fundamental tension between believing what you want and believing what you have to believe based on the information in front of you,” says Peter Ditto, professor of psychology and social behavior at the University of California-Irvine.

“There is overwhelming evidence” that hopes, fears and social connections affect our judgments, Ditto adds, “but it’s not just that we believe whatever we want. I want to be taller, but I don’t believe that because the data won’t let me.”

Since processing information and making judgments have major emotional components, the standards for evidence are skewed in favor of reinforcing our preconceptions. We are more skeptical about ideas that are new, or that conflict with our thoughts and opinions, Ditto contends.

Over the course of evolution, bad events — but not beneficial ones — forced our ancestors to focus on whether to fight or flee. “People are the same way about information,” says Ditto.

The social element in motivated reasoning surfaced in a 1950s experiment, when six people convinced a seventh, the only real subject, that two lines were equally long. One line was clearly shorter than the other, Ditto says, “But six of them are confederates, and a substantial number of [subjects] go with the obviously wrong answer. That’s the power of having other people who believe as you do. It’s much easier to believe something that does not comport with reality if a whole bunch of others” hold the same erroneous belief.

History of denialism

Although denial of global warming and the erroneous link between vaccines and autism both originated in the 1990s, the organized rejection of evolution dates to the 1920s, when some American Christian fundamentalists promoted creationism — a Biblical explanation for the diversity of life on Earth.

In a 2009 survey, 87 percent of scientists, but only 32 percent of all Americans, agreed that organisms have evolved over time through natural processes. Thirty-one percent of Americans thought humans and other living things “have existed in the present form since the beginning of time.”

Scientists and other Americans certainly have a different understanding of how organisms change through time!

Scientist data and general public data from Pew Research Center for the People & the Press surveys, May-June 2009. For question wording, see survey toplines. Numbers may not sum to 100 due to rounding. Reprinted from Pew Research Center’s Forum on Religion & Public Life.

Much of the attention to the issue comes from battles over teaching of evolution or creationism in public schools, but there is “a lot of misunderstanding,” about the anti-evolution movement in the United States, says Ronald Numbers, a professor of the history of science at the University of Wisconsin-Madison, and longtime student of the movement.

Although creationism is commonly considered a backlash against science, “Virtually nobody in the movement [in the 1920s] thought of themselves as anti-scientific,” Numbers says. “They were denying the scientific status of evolution.”

The dictionary defines science as “organized, certain knowledge about nature, and they said, ‘Nothing is certain about evolution, nobody has seen it.’”

During the 1970s, primarily in response to court decisions, creationism morphed into “creation science” or “scientific creationism,” Numbers says. “The anti-evolutionists realized that evolution had a great deal of scientific support … so their approach was that they, too, were scientific.”

Unlike most anti-evolutionists in the 1920s, the new creationists used a literal interpretation of the Bible to date creation to less than 10,000 years ago. But this created a problem, Numbers says, since according to the Bible, on the sixth day, “God created the animals and Adam named them all.”

No way Adam could rattle off the more than 1 million names of the modern species so quickly, but Numbers notes that the Bible refers to “kinds,” not “species.” If those “kinds” — created in Eden and saved on Noah’s ark — were equivalent to taxonomic families, they could have evolved into the profusion modern species.

“So creationists can accept evolution within the family, and all the evidence for speciation is welcome, because in only about 4,300 years since the flood, they have to have evolution of all the species,” says Numbers. “It’s evolution in fast-forward,” but only among closely related species.”

Even if “kind” equals family, anti-evolutionists exempt humans from this reasoning, allowing them to reject human descent from apes — our fellow hominids.

“It’s strange, I know,” says Numbers. “They are anti-evolution, but most of the evidence evolutionists use against them, they are happy to embrace! One thing that has not been true for 50 years, but lingers in the popular mind, is that creationists deny all forms of evolution.”

The manual of denialism?

Evolutionary biologists regard evolution through natural selection as the organizing principle of biology. Yet for 30 or 40 years, surveys have shown a substantial fraction of Americans, even a majority, who do not “believe in” evolution, Sean Carroll, vice-president for science education at the Howard Hughes Medical Institute, told the denial conference.

Carroll, who like many biologists is aghast at the effort to squeeze evolution into a biblical straitjacket, says, “The denial of evolution was my introduction to denialism.”

ENLARGE

American Museum of National History

In 1954, children got a “Polio Pioneer” card, and a piece of candy after getting a jab of polio vaccine.

Typically, biologists have approached the evolution debate by amassing evidence, but “it’s never been about the data,” maintains Carroll, who is also a professor of genetics at the University of Wisconsin-Madison. “And if it’s not about the data, what are we talking about?”

An earlier example of denialism occurred in the 1950s, after Jonas Salk developed the polio vaccine, a breakthrough that halted a dreaded, paralyzing disease.

Many chiropractors, Carroll found, opposed vaccines since they negated the central premise of chiropractic — that all disease results from misalignment of the vertebrae. “It shocked me. They actively opposed, disputed the efficacy of the polio vaccine. The opposed the March of Dimes, and federal and state efforts to get everybody vaccinated.”

Five hallmarks of denialism

The opposition continued — even after the polio epidemic tapered off as a result of the mass vaccination that started in 1955, says Carroll. And he identifies the tactics used then as a “playbook” of science denial that is echoed in more recent struggles over evolution, vaccines and global warming:

We just don’t agree!

Add it up, and the theme is this: The science must not be allowed to endanger a key philosophy, Carroll says.

But the cost of denialism is high, Carroll maintains. “It’s difficult, as an evolutionary biologist, to realize that half the county is deaf to anything you have to say, especially if the story you have to tell is about a magnificent achievement, understanding the complex relationship of living things on the planet, the deep history of our species.”

To reach young people, Howard Hughes has begun producing and giving away a series of videos on evolution called The making of the fittest.

Go to links for videos

Howard Hughes Medical Institute

To bring science to the masses, Hughes has produced videos on evolution; this one describes how cold-water fish evolved “anti-freeze” genes.

The idea is to engage in storytelling — to help people understand and remember facts by putting them into a narrative framework, Carroll says. As a professor, he’s seen the power of a story. “When I got lost, off-topic, and students see me years later, they say they still remember some of those stories, and I know they don’t remember any of the genetics. Stories count.”

Time (dis)honored tactics

Naomi Oreskes, a professor of history and science studies at the University of California at San Diego, has written about the “merchants of doubt.”

The message, she says, is simple: The facts are not all in. We need to hold judgment until the scientists agree.

This kind of corrosive doubt — in the face of scientific certainty — is “very depressing” if you “believe that knowledge is power,” Oreskes says. “Knowledge is not powerful enough — an ideology is more powerful still. It’s about ideas, not facts.”

During the last half-century, she says, “Political powers are willing to attack rational truths, and those who deliver them.”

There is also money at stake in many of the issues, especially in the case of climate change, which threatens the fossil-fuel industry.

Car exhaust from eutrophication&hypoxia; smoky butt from Raul Lieberwirth

What do these have in common? Many companies in the oil and tobacco industries have sown seeds of doubt about the long-term effects of their products.

The model for such campaigns, Oreskes said, came from the tobacco industry in the 1960s. Facing growing evidence linking their profitable product to lung cancer, the industry settled on a strategy of promoting “Questions, manifested in a memorable maxim: “Doubt is our product.”

And for decades, doubt helped big tobacco deride and deny a tidal wave of evidence that cigarettes cause lung and heart disease.

December, 2011, Pew Research Center for the People & the Press.

After the crazy weather of the past year, pollsters have seen a bump in the number of Americans seeing “solid evidence” for global warming.

The same strategy, Oreskes says, was adapted to undermine “nuclear winter” (the discovery that huge clouds of ash and dust released during nuclear war could freeze and starve the planet), the dangers of the insecticide DDT, acid rain caused by power-plant pollution, the ozone hole, and global warming.

The tactics were to “challenge the evidence, claim the science is not settled, cherry-pick the data, to demand balance from journalists and threaten to sue if they don’t,” says Oreskes.

Changing the climate change story

The basic physics of global warming have been known for 100 years, Oreskes said. Scientists started exploring the subject with early computerized climate models in the 1980s.

In 1992, Oreskes said, the first President George Bush, “Called for concrete action to protect the planet. We had political leadership that committed us to doing something, yet we never did take the concrete steps that Bush called for. It’s a story about political challenges, selling uncertainty, about science in the age of denial.”

The doubters, funded by the oil industry, included some prominent Cold-War physicists who had been advocates for Ronald Reagan’s anti-missile defense system. “They said the science was unsettled, that it would be premature to act,” says Oreskes, who was intrigued to find that one of those physicists, Frederick Seitz, had been a consultant to the R.J. Reynolds tobacco company.

In 1998, Seitz organized a petition against the Kyoto Protocol, the first international agreement to control greenhouse gases.

Seitz and his fellow doubters, Oreskes says, “Found a new enemy: environmental extremism. You see anxiety about environmentalists as socialists, using climate change as a lever to effect social or economic change.”

What began with a handful of people with roots in the Cold War has since spread to “a range of free-market think tanks, including the Cato Institute and the American Enterprise Institute,” Oreskes says.

The arguments against the settled scientific debate over warming, she adds, “are not just different interpretation of the data; that’s a normal part of scientific life. This is not about normal scientific claims. These are the scientific equivalent of saying Belgium invaded Germany during World War I.”

Why deny? Because it works, Oreskes implies. Almost 25 years after the scorching summer of 1988 brought global warming into the public sphere, the United States has yet to get serious about controlling greenhouse gases.

“We ignore the facts of nature at our peril,” says Oreskes. “Ignoring them is not going to make them go away.”

Microsoft’s April 9 deal to spend $1.3 million apiece on 800 patents from AOL was another skirmish in the patent wars that have engaged the technosphere. Just last summer, we watched a blizzard of headlines, lawsuits, and billion-dollar bills:

We wonder: Is this a situation that only a patent lawyer could love, or are these purchases and lawsuits the inevitable price of progress in our high-tech world? Are they the inevitable outgrowth of a venerable system that, for all its flaws, is still better than nothing?

Patents are licenses to exclusively make and market an invention that are inscribed in the U.S. Constitution. The concept is simple — and ridden with inherent conflict. If you invent a small device (a “midget widget”) that is new, useful, and “not obvious” to people skilled in the art of widgetry — your widget can be protected by a U.S. patent.

If I make or sell a widget that uses your invention (that “infringes on your patent”), you can sue me for damages, and a court may order me to close my widget-works.

So far, my invention has benefited me, my employees and customers, but when the patent (which must explain the inner workings of my midget widget) expires after 20 years, it becomes available to anybody.
And so (in theory) patents stimulate innovation and progress by conferring a short-term monopoly in return for short- and long-term social and economic benefits.

But what sounds good on paper can hide complexities that only a patent lawyer could love:

“Greasing the wheels of innovation” or “throwing sand in the gearbox”?

It’s not hard to find claims that the patent system is “broken,” and nobody disputes that “bad patents” have been issued for innovations that are obvious, inane or unworkable.

Patent battles are nearly as old as the U.S. patent system: Eli Whitney spent years in court trying to enforce his patent against infringers who cobbled together homemade cotton gins. His “victory” came just one year before the patent expired.

Lawyer-letters about patent infringement are a dreaded fact of life in technology industries, but no matter who wins, patent battles transfer money from the buyers of phones and computers to patent lawyers.

The pace of U.S. patent awards has picked up to about 200,000 per year, and some with a dog in the fight say the system does protect the rights of inventors.

The sentiment is not universal.

Adam Jaffe, an economist at Brandeis University, co-wrote a book on the patent system² that refers to a “broken patent system” in the subtitle. Jaffe says patents cut both ways. “Patents are important in fostering innovation, because 99.9 percent of the time, inventing something is just the first step. You require a significant investment … to get something from the invention stage to actual production, and unless you are independently wealthy, you need someone who is hoping to make money to take you through the development stage.”

And that “someone” may view a strong patent as your most valuable asset.

Software and high-tech patents?

Innovation “is a very complicated process,” Jaffe adds. “In most cases multiple ideas are interacting. In the extreme case, in software and high technology, people say a product might invoke 100,000 patents. It can get very messy.”

When the United States started issuing large numbers of software patents in the 1990s, the inexperienced patent examiners issued many dubious patents. Although the examinations have gotten more stringent, some still think software should be exempt, or patented under different standards.

Searching for competing inventions in software, for example, is comparatively difficult, and the search is the basis of the patent examination.

In most cases, says Tim Berners-Lee, a commentator on tech issues, software developers don’t bother doing thorough patent searches, which, he maintains, could require more patent lawyers than exist on earth.

Trolling for profits?

Although patent disputes are nothing new, they have been systematized by “patent trolls” — companies that own, defend and license a library of patents. Depending on your point of view, trolls are:

NPR covered a prominent case of trolling, complete with shadowy, unoccupied offices.

But even if trolls can be a barricade to innovation, “in practice it will be very difficult to change the rules in such a way as to prevent that,” says Jaffe. Would you allow infringement suits only from those who are moving a patented idea toward the market? “Say I’ve got an invention and am looking for a company that has the resources to bring it to market… and someone else comes along and steals the idea. Are you saying I can’t sue because I am not on the market?”

As with many parts of the patent system, finding faults is easier than fixing flaws, he indicates. “I don’t disagree that in a sense people are abusing the system by amassing piles of patents, but it’s naïve to think you can tweak the system to shut that down.”

First-to-file, or first to invent?

The America Invents Act, signed into law September, 2011, made what former commissioner of the Patents and Trademark Office Robert Stoll calls “the most revolutionary change in patent law in 60 years.”
The changes start with the basis for obtaining a U.S. patent. Previously, you had to prove that you were the first to invent something; now you must be the first inventor to file.

“First-to-file” will make life simpler, Stoll told an audience at the University of Wisconsin-Madison in April, by deleting disputes about who made the invention first. “First-to-file provides more certainty to the system, and reduces the ugly interference cases that don’t provide much benefit to the United States.” (An interference proceeding now determines whether someone made the invention before the patent applicant.)

“First-to-file really favors large companies that have sufficient resources to get to the patent office first,” argues Carl Gulbrandsen, managing director of the Wisconsin Alumni Research Foundation (WARF), the private, not-for-profit technology transfer arm of the University of Wisconsin-Madison, “and it disadvantages independent inventors and universities. I expect filing costs will go up.”

Got an app for that patent?

Here’s the snag: When you invent a molecule that could make a tire last forever, you may not know right away if it’s worth filing a patent application. Under first-to-invent, you could wait as much as one year to file.

Filing a patent can cost tens of thousands of dollars, which is money you could better spend on research that might show that your invention is solid — or as evanescent as a rainbow.

But under first-to-file, you lose if an inventor in Berlin or Tokyo files an app before you have time to decide. “AIA has weakened the grace period and the ability of independent inventors to test out the invention, and appropriately get financing to help with filing,” says Gulbrandsen.

Gulbrandsen also charges that the new law contains, “So many undefined terms that they will be litigating it for 15 years. They have essentially thrown out 100 years of case law; it’s a full employment act for lawyers.”

Winnowing the chaff — or weakening the patent system?

Although interference proceedings are now history, Gulbrandsen says AIA contains too many new ways to challenge patents. “There used to be two principal ways to attack a U.S. patent, and that made them strong. Now there are literally nine ways, and that weakens them overall. For a university, this will mean increased expense [for defending existing patents], and many of them won’t be able to bear that.”

Since its founding in 1925, WARF has contributed $1.24 billion to UW-Madison as royalties from more than 2,300 patents for inventions by university researchers. It has become a significant source of income to the university’s researchers and a model for other university patent offices.

A strong patent system has benefited the United States, says Gulbrandsen. “It’s necessary for innovation, and the last thing you want to do, if you want to create jobs, is to weaken the patent system, and that is exactly what we have done” with AIA.

But Jaffe, although no fan of the patent system, sees a benefit in these after-the-fact challenges, since “the vast majority” of the 200,000 U.S. patents granted each year are trivial (like that baling-wire-and-chewing-gum flying machine). Because the patent office must judge a flood of applications with limited resources, “It cannot do an exhaustive analysis, and it would be crazy to invest the resources to get it right every time.”

Under the new system, after the initial patent examination culls the obvious chaff, Jaffe says, competing inventors could contest a wobbly patent. Now, he says, “You have the opportunity, at least in theory, to go to the patent office and say, ‘This wasn’t really novel.’”

Although it’s easy to criticize the patent office, Jaffe says it has more expertise than the federal courts, the final resting place for most patent disputes.

Who benefits, who gets hurt?

In the ideal world — where patents are perfectly drawn — innovation wins. “I equate patents and innovation,” says Gulbrandsen. But despite its promising moniker, the America Invents Act “makes it more difficult for the inventor to raise the funds necessary to bring the invention to market. One of the best tools an entrepreneur or a startup has to raise money is a patent. It gives some assurance to investors that if they provide the funding, they will be able to recover it and get a return. The patent gives you the right to exclude others. Weakening the patent system increases the risk for investors, and that’s bad for inventors.”

University technology-transfer offices are going to suffer, says Gulbrandsen, who directs one of the oldest and largest in the nation, since many of them must wait to file a patent until they have found a business that wants to pay for filing and license the patent. “Although WARF is an exception, under first-to-file, you don’t have time to find a licensee, and so most universities tech-transfer offices will drop out.”

Individual inventors, Gulbrandsen notes, seldom have a patent lawyer on retainer.

Still, too much protection stifles innovation, says Jaffe, who says the system requires balance. “I don’t think first-to-file changes a lot. The rest of the world has been on that for a long time. There are going to be impacts in both directions, but in most cases, first-to-invent is just a source of conflict, because it’s harder to establish. This just simplifies things and reduces controversy, which is a very good thing.”

Scientists have thought for a decade that iron-bearing structures in the homing pigeon’s beak help the bird find its location by “reading” Earth’s magnetic field. Now, it turns out that this iron occupies cells that battle infection, rather than nerve cells.

Oops!

The new results leave a chasm in our understanding of bird navigation, says Charles Walcott, an expert on the subject at Cornell University, who was not involved in the study. “It’s astonishing that we have what seems like a terribly simple-minded problem. Take a homing pigeon any direction, and after circling a couple of times, it heads for home … and we don’t understand how these animals do this?”

Study leader David Keays, of the Institute for Molecular Pathology in Vienna, did not set out to debunk a beautiful theory, but rather to explore the nerve cells in the beak that supposedly register magnetism. “My background is in molecular biology and genetics, and I thought there must be some incredible biology involved. I wanted to get a handle on the molecules and create an artificial receptor.”

Because the “magnetic neurons” in the beak contained iron, Keays applied a blue stain that gloms onto iron. Christoph Treiber and Marion Salzer generated one-quarter million slices for microscope slides, each one-hundredth of a millimeter thick.

(Makes us dizzy … Didn’t they outlaw slavery?)

A fly in the ointment!

Although the magnetic neurons were said to number just six, iron-rich cells showed up all over the beak. One beak had about 108,000 blue-stained cells while another had just 200, Keays says. “This did not make sense. If these were magnetoreceptors, we would expect a similar number in birds of the same age and sex.”

When the scientists treated the samples with stains that attach to neurons, there was almost no overlap with the iron-bearing areas.

As questions accumulated, the researchers got a lucky break. One bird’s infected beak attracted blue cells that resembled macrophages, immune cells that fight infection (and also process iron). “You could see the cells’ tentacles engulfing other cells,” Keays says.

Stains that attach to immune cells overlapped heavily with the iron stain, Keays says; further evidence that the iron was inside macrophages, not neurons.

The study is “quite interesting and convincing,” says Walcott, and it explains why scientists have found no connection between the iron crystals and the nervous system. “If this is going to be seen as a sense organ, I think the two ought to be connected.”

Paradigm paranoia

Although the new study overthrows the accepted explanation for the pigeon’s magnetic mastery, Walcott says magnetism isn’t the whole story in navigation; birds also use vision, memory and smell.

Looking at the sun can help the bird figure out direction, but magnetic methods are needed to find a location on the globe.

Confusingly, birds seem to have a mechanism in the eye that detects Earth’s magnetic field. But because this works only when the sun is shining, it’s unlikely to explain nighttime navigation.

Keays says attitudes have changed since he “released a cat among the pigeons” at a conference a year ago. “Half of the audience wanted to hug me, they had been very skeptical, but the other half wanted to kill me.”

Since then, however, “We were able to persuade some big players in the field that the original reports were wrong. I think the great thing about science is that it is a self-correcting enterprise. If we get it wrong, somebody is going to come along and work out what the truth is.”

At this point, though, mystery rules. “It’s absolutely clear that birds, pigeons, can detect magnetic fields,” Keays says, “but the way they do that is the mystery.”

On March 10, atmospheric chemist “Sherry” Rowland of the University of California-Irvine died in the company of his son and his wife of almost 60 years. Rowland became prominent in the 1970s after warning that common chemicals would destroy ozone 10 kilometers above Earth, exposing life to a shower of harmful radiation.

While exploring how chlorofluorocarbons (CFCs) degrade after being released into the atmosphere, Rowland and graduate student Mario Molina realized the CFCs would float to the upper atmosphere, be cleaved by sunlight, and release chlorine that would destroy ozone through a chain reaction.

(Ozone contain three oxygen atoms; most oxygen molecules contain two oxygens.)

By intercepting cancer-causing UV radiation, ozone in the stratosphere allows life to exist on Earth. Significant damage to this ozone would cause an epidemic of human and animal cancer, and likely damage plants as well.

This alarming prospect was not popular in industries that relied on CFCs, but it sparked a long and largely successful effort to restrict and then ban production of the chemicals.

And although Rowland never retreated from his findings, his calm, charismatic personality helped his cause. Ralph Cicerone, now the president of the National Academy of Sciences, recalls collaborating with Rowland on CFCs. “We talked on the phone nearly every day. I considered Sherry to be my best friend, and over time I learned that many people considered him to be their best friend, too. In the midst of the debates over CFCs, he never exaggerated the dangers, always cited the science, and treated other people with dignity and respect.”

What must a scientist do?

According to the University of California-Irvine’s press service, Rowland knew his results mattered far beyond the lab: “Mario and I realized this was not just a scientific question, but a potentially grave environmental problem involving substantial depletion of the stratospheric ozone layer. Entire biological systems, including humans, would be at danger from ultraviolet rays.”

At the time, scientists were studying the health implications of ozone-bearing smog in the lower atmosphere, but few people knew or cared about “good” ozone in the stratosphere.

The sudden notoriety of CFCs had a certain irony: The chemicals were invented in the 1920s at General Motors, maker of Frigidaire brand refrigerators, as a stable, non-toxic alternative to the ammonia and explosive propane used in air-conditioning and refrigeration.

CFCs later were used to expand plastic foam, clean electronic parts, and propel paint and deodorant in the mushrooming aerosol-spray business.

Antarctic ozone hole, 2011

   

Video: NASA

Chlorine and bromine in the upper atmosphere cause rapid ozone destruction in the super-chilled polar winter. Although the ozone “hole” (blue) is declining with the phase-out of CFCs, it still recurs.

They publish lest we perish!

Rowland’s 1974 study¹ ignited a long squabble over CFC production. Aerosol Age, the spray-can industry’s trade journal, implied that Rowland was a member of the Soviet KGB who wanted to destroy capitalism!

CFCs remained a back-burner issue, however, until the British Antarctic Survey discovered an alarming absence of ozone in 1985. The “Antarctic ozone hole” gave the theoretical worry sudden significance, and as the industry gradually found substitutes for CFCs, the ozone hole stopped expanding.

Today, as we watch the faltering response to global warming, it’s comforting to recall that the ozone threat prompted prompt collective action: The Montreal Protocol, a treaty to restrict CFC production, became effective in 1989 and has since been tightened after further alarm over ozone destruction, and 196 nations — essentially all of them — have signed the original Protocol. Production of ozone-depleting substances has fallen by more than 95 percent.

“CFCs were extremely useful compounds and their use was pervasive,” says Rudy Baum, editor in chief of C&EN (Chemical and Engineering News). “Although manufacturers maintained that there would be dire consequences if the use of CFCs were restricted or banned, it became clear pretty quickly that alternatives could be found in most cases.”

And yet ozone is still a problem, as shown by a 40 percent drop in Arctic ozone in the winter of 2010-2011. Continuing destruction is blamed on the stability of CFCs and the fact that the replacements, while less damaging, still destroy ozone. “Ozone can be thought of as a patient in remission, but it’s too early to declare recovery,” said Susan Solomon of the University of Colorado.

Not bounded by the lab walls

Nonetheless, the Montreal protocols are considered an epochal case of planetary preventive medicine, and Rowland, Molina and Paul Crutzen, who also worked on CFCs, were awarded the 1995 Nobel Prize for Chemistry.

But for 10 or 15 years, Rowland had played the role of maverick — speaking outside the laboratory about the importance of what he had found inside it. It’s not a comfortable role for many scientists; many find it safer to stay in the lab and let others figure out what to do with their results.

Jonathan Fink, vice-president of research at Portland State University, says “The culture of science is pretty deep in terms of how we are trained. Most science grad students are taught to focus on being the best at something, rather than thinking about the application of what they do to society.”

All along, Rowland explained the science and gently reminded us of our stake in an intact ozone layer. He continued to study atmospheric chemistry, mentor younger scientists, and show by example how scientists could speak responsibly about what their results mean for the rest of us.

Somehow, Rowland managed to fight his battles without making enemies, at least outside the industries that had inadvertently begun calamitous destruction of ozone.

Why do scientists like Rowland speak out? “Because they’re scientists and scientists are addicted to facts and what facts tell them,” says Baum. “I knew Sherry Rowland pretty well — I was the West Coast correspondent for C&EN from 1991 to 2004 … he was a gracious, dignified, reserved individual, certainly not a rabble-rouser. But he knew that his science was solid and that it told him that humans were doing something that would have catastrophic consequences if they didn’t stop. So he spoke out. Simple as that.”

A new disaster unfolds

Even before the Montreal Protocol was signed, climate scientists were starting to warn that carbon dioxide in the atmosphere would enhance the greenhouse effect and trigger global warming. In testimony to the U.S. Senate in the torrid summer of 1988, NASA climatologist James Hansen linked rising temperatures to rising levels of greenhouse gases from fossil fuels.

The debate over global warming and climate change had begun, and going public put Hansen in much the same position as Rowland had occupied 15 years before. Via email, Hansen credited Rowland and atmospheric scientist Don Hunten as “role models… . They showed that it was possible to do first-rate science and also uphold our responsibility to make clear the implications of our research for society.”

Rowland redux?

Until then, Hansen had been a well-regarded but faintly visible NASA expert in planetary atmospheres. He had studied Venus, where an atmosphere choked with carbon dioxide produces a “runaway greenhouse effect” that raises the surface temperature to 460° C.

After making news in 1988, Hansen retreated from the public discussion of warming, but in the early 2000s, as temperatures continued to rise, he began to speak up again. In 2005, after the Bush White House tried to muzzle him, he went public with a vengeance.

Why? Journalist Mark Hertsgaard, who has written extensively about global warming and repeatedly interviewed Hansen, says he “thinks like a scientist, believes if you find the information, and present it properly, the truth should carry the day. I think he came out of hibernation in 2005 only because he felt he had to. He looked around and saw that the information alone was not carrying the day.”

Hansen’s regular emails combine climate facts with political opinions for a broad audience. For example, a recent commentary argued that “Scientists attempt to communicate, but are flummoxed by the ability of the profiteers to manipulate democracies. The scientific method (objective analysis of all facts) is pitted against the talk-show method (selective citation of anecdotal bits supporting a predetermined position).”

On Aug. 29, 2011, Hansen was arrested at the White House with hundreds of others protesting the Keystone XL tar-sand oil pipeline. Tapping such a vast reservoir of carbon, Hansen believes, will bring us that much closer to a “tipping point” on greenhouse warming. “Now we’ve got the spectacle of one of the world’s foremost climate scientists getting arrested and urging others to get arrested,” says Hertsgaard. “This is way beyond speaking out.”

Hertsgaard, a native of Minnesota, says it’s “very hard for [Iowa native] Jim Hansen the person to speak out.” In the Midwest, Hertsgaard says, “it is just not seemly to draw attention to yourself or bring up a topic that is likely to discomfort others. … but it’s not corny to talk without irony about the importance of doing the right thing.”

The scientific culture

A fully indoctrinated scientist is chary of talking much beyond the lab, Hertsgaard says. “Many scientists very much frown on taking the public agitator role, and that’s another tribute to Hansen’s courage. He was prepared not only to take brickbats from the Exxon-Mobil front groups, but to endure the judgment of his own peers, who said ‘That’s not what scientists do.’ He remembers that he’s not just a scientist, he’s a human being too.”

Despite the successful example of the Montreal Protocol, the global warming problem is vastly harder to solve, says Baum of C&E News. “The scale of fossil fuel use is several orders of magnitude larger …. Humans consume between 80 million and 90 million barrels of petroleum every day, and that represents only about a third of the fossil fuel that is consumed.”

Finally, while the specter of cancer caused by increased UV radiation is unsettling, “people actually like the warmer conditions, at least for now,” Baum wrote. “We didn’t have a winter in Washington, D.C., this year … and people loved it.”

So will the environmental victory over CFCs that started with Rowland and Molina be mirrored by serious action over global warming? Maybe not, says Spencer Weart, a long-time chronicler of warming. Comparing the ozone battle to the fight over global warming “is like comparing a single battle to a world war. Ozone depletion (once the ozone hole was detected) was clearly an urgent problem, with a straightforward solution. But with global warming, it’s hard for people to worry much about something that seems remote in space and time — isn’t it just a problem for polar bears and our grandchildren?”

Slowing warming “will require wholesale changes in our entire world economy,” Weart says. “And that must begin with government regulation of the fossil fuels industry, the largest concentration of economic power the world has ever seen. The pushback has been fierce, beginning with industries that suspected their profits would be restricted, and extending to people who fear governmental threats to their freedom.”

Rowland was once libeled as a Soviet spy, but “Scientists who have put themselves into politics like Jim Hansen … have been subject to ad hominem attacks: crude vilification and direct threats far beyond anything that Rowland experienced.”

Hansen and his colleagues, says Weart, “have persisted nevertheless. For the logic of their scientific understanding forbids them from keeping silent about the dangers they foresee.”

Running short of worries? Then ponder the super-volcanoes — earth-bombs that can vomit 10 or 100 or 1,000 cubic kilometers of molten rock. Super-volcanoes can change history by creating rivers of red-hot ash moving at highway speed, spreading dust across hundreds of kilometers and spewing vapors that block the sun, destroy crops and start famines.

A volcano may go dormant for thousands of years after such a huge eruption, so they may be even harder to predict than smaller ones — which are also unpredictable at this point…

But this week, Nature published a new analysis of Santorini, a Mediterranean monster, that shows the movement of molten rock that preceded the eruption.

Santorini’s sudden release of 40 to 60 cubic kilometers of rock and ash was followed by a giant collapse that left a characteristic ring of hills called a caldera. Thousands may have died in the eruption, which laid down a 60-meter layer of ash and rock.

Eruptions of this general size happen about every 300 years, says Timothy Druitt, a volcanologist at the Université Blaise Pascal in France, who lead the current study. The most recent was in 1815 at Tambora, in Indonesia.

Druitt’s new analysis of crystals within the frozen magma offers a rough schedule for the entry of molten magma into a holding tank — the magma chamber — below the volcano, which is a precursor to eruption.

Caldera-forming eruptions rival earthquakes and tsunamis as the deadliest natural disasters. “People who work in the field know these volcanoes are not rare, even on a human time scale,” says Druitt, but “we have never been able to monitor one of these big eruptions during the long buildup phase, so we are not really sure how that happens.”

The crystal analysis detects microscopic changes in chemical composition, offering a unique, after-the-fact picture of the gestation of eruption.

In the crystals

As crystals grow in the cooling magma, atoms of trace elements diffuse within them, and both growth and diffusion are affected by conditions within the hot magma, says Druitt. “These crystals grow progressively, and as they do, their chemical composition changes according to the composition of the magma around them, and the temperature and amount of water in the magma.”

The crystals revealed that a big gob of magma — perhaps 10 percent of the magma chamber’s total contents — entered in the decades before the eruption. “Looking at the crystals in this magma, we were able to reconstruct very crudely events taking place in the last few decades prior to the eruption,” Druitt says.

That final addition probably made the magma chamber unstable, leading to the eruption, Druitt explains.

If such a late, large magma movement proves typical of super-volcanoes, that could contribute to a distant early warning system for mega-eruptions, based on more conventional methods, such as seismic monitoring.

Distant early warning

But the findings also carried a caution, Druitt says, since Santorini was apparently dormant for about 18,000 years before the last apoplectic outburst. “That is a slightly alarming result. There are lot of these big caldera systems, but most are in a stage of repose.”

The upshot is more proof that a dormant volcano can still be a dangerous one, he adds. “We can imagine that a big caldera in a remote region of the world, such as the Andes, which is not monitored very well, could reawaken pretty quickly on a human time scale.”

The crystal method gives after-the-fact data on an eruption. Current attempts to anticipate eruptions rely on data about earth shaking, deformation of the crust, and release of gases.

“It’s a very timely topic, and solid science in terms of the measurements and observations,” says Bradley Singer, a volcanologist and professor of geoscience at University of Wisconsin-Madison. “They admit that there are issues about the time scales,” largely because the diffusion of strontium and titanium is imperfectly understood in the hot magma.

The study’s title, however, specifies that the final growth of the magma chamber occurs on “Decadal to monthly timescales,” Singer notes. “It could be centuries or even longer, which implies that we’d have a longer time prior to the eruption” to worry about the effects of the rising magma.

Singer concurs on the importance of understanding the relationship of magma flows, instability and eruption, and says the crystal analysis is gaining traction in volcanology.

That’s just as well, since giant caldera-forming volcanoes may be frighteningly common. The one at Yellowstone, for example, released 1,000 cubic kilometers of rock 640,000 years ago. Wouldn’t you want to know if something like that was building on your continent?

In Africa, elephants trample farms. Some traditional herders are prohibited from grazing their herds on land occupied by tourist-magnets like lions, leopards, giraffes and gazelles.

And buffalo, zebras and antelopes eat grass that could feed cattle.

In the East African savannas, the interactions between wildlife and the people whose livelihood depends on cows and goats, are complicated, critical and contentious.

Grazing is about the only way to make a living in this hot, dry land, but livestock and many wild herbivores eat similar vegetation.

And so the competition is obvious: How can a cow eat forage that a zebra ate first?

The question answers itself, and so nobody studied the issue.

Not so obvious after all

But in other realms, ecologists have found that organisms that seem to compete may actually aid each other. “We are just beginning to understand that the relationship between species is highly contextual,” says Truman Young, a professor of plant sciences at the University of California at Davis, “and this interaction includes competition and facilitation. Once, people thought if two species were similar, they always competed, but years ago, it became clear that facilitation exists in certain situations.”

Young is senior author of new study showing that in Kenya’s highland savannas, competition is partly offset by facilitation; although during the dry season wildlife steal food from the mouths of cattle, so to speak, the situation is reversed during the wet season.

When the rains come, wild ungulates (mammals with hooves), particularly zebras, seem to benefit cattle by eating fibrous, woody grasses and revealing the more delectable, higher-protein grasses beneath.

This gives cattle access to forage with more protein, and their wet-season weight gains nearly counterbalance the dry-season losses inflicted by wildlife.

Well done

The study was performed during 2007 and 2008, on nine fenced plots, or “exclosures,” each 4 hectares in size. The researchers placed four young, unbred females of an African breed called Boran on each plot for 16-week periods, and measured their eating habits and weight gain in three conditions:

First author Wilfred Odadi, a postdoctoral researcher at Princeton University and the African Wildlife Foundation, wrote us to explain that facilitation nearly equaled competition. “Wildlife-driven depression of cattle weight gain in the dry season is 35 to 40 percent. In the wet season, cattle put on weight faster by about the same percentage when they forage with wildlife.” The real-world situation, he added, would “depend on the lengths and frequencies of dry and wet seasons.”

This was the first experimental evidence that wildlife and livestock are engaged in facilitation and competition, Young says. “There is a basic-science excitement here. With this large-vertebrate system, we have shown that you can actually sometimes have competition and sometimes facilitation.”

It’s possible that the 15-year history of experiments on the site has changed the vegetation enough to weaken the results. But the continuous grazing of cattle kept the site’s vegetation similar to the surrounding savanna, Young says. “If we had excluded all large herbivores, the rangeland would become very different, and our inferences would be skewed. But because cattle are the dominant herbivores … the plots were not that different. My belief is if we had started the exclosures last year, we would have gotten the same result.”

What are the practical implications?

Killing wildlife, except for rogue animals, is illegal in Kenya, but it still happens, Odadi told us. “Because in Kenya wildlife belongs to the state, and not to the land owner, some livestock keepers still show a negative attitude towards wildlife because of perceived ‘detrimental’ effects on livestock including competition, livestock depredation and disease transmission. Some people react by fencing off their properties to keep wildlife away. There are also situations where water sources are fenced off by pastoralists to make them inaccessible to wildlife. In extreme cases, wild animals are actually killed, albeit illegally.”

And so in a region with unreliable rainfall and few resources, it’s good news for advocates of biodiversity conservation that the competition between domestic and wild ungulates, at least on savannas, may be more apparent than real.

Good news for conservation

Indeed, large mammal ecologist Johan du Toit of Utah State University, wrote in Science that the new information should eventually “provide managers with opportunities to capitalize on facilitative interactions, intervene against competitive ones, and enhance animal production overall.”

Rangeland managers often mix native and non-native plants, du Toit added. And after “bold experimentation and a break from orthodoxy,” a similar approach with animals could boost production while conserving biodiversity.

Odadi says better knowledge of cattle-wildlife interactions could support short-term changes, such as slaughtering or marketing livestock “at the end of the wet season, when they have recovered from competition in the preceding dry season, and also to minimize competitive effects (by reducing densities) in the next dry season.”

Conservationists in East Africa and elsewhere are seeking “to manage land for ecosystem biodiversity and short-term extractive value,” says Young, “but it’s pretty hard to find good examples, other than assertions about the profitability of ecotourism. We were able to show that wildlife and cattle have a complex interaction; that wildlife is not uniformly bad for cattle, and that allows us to be a little more lenient toward wildlife.”

– David J. Tenenbaum

We approach the Cave of the Mounds, a landmark (so to speak) in Southwest Wisconsin, along a walkway painted with fossils and markings that start at the Ordovician era (450 million years ago), when the limestone beneath our feet was deposited as a rain of sea shells on an ocean floor. Finally, at the cave’s entry, the asphalt calendar enters the last million years, when the cave started to be excavated by flows of acidic water.

The geological markings under our feet are one indication that the cave-men and -women who operate this site are intent on linking past and present, above- and below-ground.

Cave of the Mounds was discovered in 1939 by workers blasting in a limestone quarry on one of the highest spots in southern Wisconsin. Today, it is a tourist destination with a message — a cool, underground mecca, strategically illuminated, where tour guides leave the nettlesome lectures above ground, and offer easy-to-digest science along the cave’s alleyways.

The above ground section of the site features resurrected prairies and oak savannas, but the main attraction is the stalactites hanging over stalagmites, flowstone, the fossils embedded in ancient limestone, and the rare opportunity to see geology at work as you observe the earth from the inside out.

Aftermath of a flood unparalleled

What caused the huge erosion features, ancient shorelines, and scoured potholes in the “channeled scablands” in Eastern Washington state? In 1923, J. Harlen Bretz coined that ominous moniker and proposed that the features had been created by a gigantic flood.

During this time, geology was ruled by a “uniformitarianism” dogma, which highlighted gradual processes like deposition and erosion, and discounted the power of sudden events like floods (and perhaps even earthquakes, tsunamis and volcanoes).

Skeptics demanded to know the source of all that water in an arid region, and Bretz had a reputation as a kook. Then, geologists gradually realized that the ice-age flood had originated to the east, in glacial Lake Missoula, which had been plugged by the lobe of a glacier emanating from Canada.

In the 1950s, the idea that this huge lake had eaten through an ice dam and then coursed downstream with phenomenal power started gaining acceptance, and in 1979, Bretz, age 96, received the highest award from Geological Society of American for solving this great Earth riddle. Today, scientists believe the floods may have recurred every few years or decades as the ice age was waning, around 14,000 years ago.

The evidence for the floods comes in all sizes. Alternating stacks of coarse gravel and fine sand show gravel left by flood currents under sand left by slower water when the floods receded. A dry river bed called the Grand Coulee, in Eastern Washington, was gouged by the astonishing flow of uncorked glacial melt water. The periodic cascades that shaped Dry Falls, now in Sun Lakes State Park are considered the largest known waterfalls in Earth’s history.

The unbearable whiteness of being

The world’s largest field of gypsum dunes, at White Sands National Monument in south-central New Mexico, could arouse anybody’s inner drywaller, as gypsum is the mineral basis for both drywall and plaster. But here, where 275 square miles of gypsum dunes have built a hot, severe and scorchingly beautiful landscape, there’s not a sheet of drywall in sight.

Set aside as a national monument by President Herbert Hoover in 1933, the dunes trace their origin to vast deposits of hydrated calcium sulfate — gypsum — that were laid down on an ancient lake a quarter-billion years ago. After a geological uplift, they were exposed roughly 10 million years ago, and eventually moved to the present site in a geologic eye-blink — the last 7,000 years.

Mammoth tracks have been seen in the dunes, but they could get buried with time: Some dunes are moving 30 feet a year, as the wind piles them up on the windward side and gravity avalanches them down the lee.

The gypsum dunes are said to be the largest in the world, but what’s most amazing is not the geology, but the evolutionary adaptations life has used to survive these harsh conditions. At least seven species of animals, including three lizards, that are closely related to darker varieties living in the surrounding desert have turned white for camouflage in this bleached world. (The drywalling lizard or the plastering mouse must be here somewhere!)

Visiting the Sands? Ponder a trip to Trinity, the site of the first test of the atomic bomb.

Science museums: Try the trifecta!

The Windy City boasts not just one, but three cool science destinations, all next door to each other on the Museum Campus along the shore of Lake Michigan.

To explore some of the world’s biological and cultural wonders, spend the day at the Field Museum of Natural History, a collision of anthropology, botany, geology, paleontology and zoology. The permanent exhibits include the DNA Discovery Center, a journey through four billion years of earthly life, and Sue, the largest (and most expensive?) complete skeleton of the ferocious T. rex. Among the temporary exhibits was a recent one on the horse and its deep relationship with humans (an exhibit that particularly excited one horse-crazy Why Filer).

If your palate is whetted for a wetter world, walk to the Shedd Aquarium to explore underwater life from the Amazon, the Caribbean and both poles. Green sea turtles, beluga whales, moray eels, piranhas and penguins will be among your hosts.

If otherworldly science is more your thing, visit the Adler Planetarium. Chat about the stars with real space scientists at their Space Visualization Laboratory, or just sit back and watch the star show. Adler’s centerpiece is the Doane Observatory, the largest publicly accessible telescope in the Chicago vicinity. While you can only peer through the lens after dark, this could make for a great conclusion to your trip.

Discover a life aquatic

An Australian freshwater crocodile grows in Baltimore. Seriously. The National Aquarium Baltimore boasts more than 660 species of fish, birds, amphibians, reptiles and mammals, totaling around 16,500 marine creatures.

In addition to its rich marine menagerie, the aquarium has a collection of special exhibits and interactive oceanic enjoyment. See the world through a dolphin’s eyes at Our Ocean Planet, a show that teaches visitors about dolphins and the connections between people and their seafaring friends. Or soak in ocean sensations with a movie at the 4-D Immersion Theater, where you can experience sea life in multiple dimensions, including the smell and feel of (simulated) mist and wind. Or take an expert-led tour, including behind-the-scenes peek of the sharks’ quarters.

The aquarium is also a center for conservation. For example, its Marine Animal Rescue Program tracks the progress of rescued animals after release. Other conservation projects include restoring wetlands and investigating the impacts of mercury on the marine food chain. After all, protecting the life that sustains the ocean ecosystem benefits everyone—not just aquarium visitors.

An excursion exotic to Melville

What’s more breathtaking than seeing the world’s largest animals in the wild? Whale watching puts you up close and personal with these magnificent marine mammals. Since the 1950s, in a 180° turnaround from Herman Melville’s day, people have been flocking by the boatloads to glimpse whales doing what they do rather than to kill them.

Both the U.S. east and west coasts have whales to watch, though you must catch them in the right season during their migration. There’s no guarantee, but on the western seaboard, you could spot orcas and gray whales. The east is home to the right, fin and sei whales. Humpbacks, minkes, and blue whales troll both coastlines.

Several cetaceans (a scientific category including whales, dolphins and porpoises) are endangered, including the North Atlantic right, blue, fin, sei and gray whales. In any case, marine mammals are heavily protected by law, so whale watching should be done with professionals who obey the rules.

Celebrating, protecting southern nature

With more than 500 full-time employees and an annual budget exceeding $30-million, Audubon Nature Institute sounds more like a business than a private, non-profit organization dedicated to explaining and preserving the wonders of nature with a Cajun flavor. The group operates a zoo, aquarium and assorted parks in and around New Orleans. The Aquarium of the Americas focuses on the Caribbean, Amazon, Gulf of Mexico (complete with oil-drilling replica) and Mississippi River.

A primate exhibit in the Audubon Zoo shows dozens of our opposable-thumbed relatives. Its 360 species of animals include a jaguar shown in a replica Amazon jungle. The “Embraceable Zoo” is devoted to full-contact animal admiration, and you can also eyeball, if not pet, a prickly Indian crested porcupine. Audubon maintains two locations that focus on captive breeding and survival of endangered species; these are closed to the public, but we expect to see you at the new insectarium, located in the old Federal customs house, for the beetle races on Sept. 3.

North Carolina: decapitation capitol

Every summer, vacationers flock to North Carolina’s coast for a beach getaway. But beach vacations would have been a hard sell early in the 18th century, as the coast was the stomping grounds of the South’s most feared pirate, Edward Teach, otherwise known as Blackbeard.

Nowadays, the area is proud of its sordid past, attracting pirate-curious tourists and archaeologists alike. In 1996, Blackbeard’s biggest and final ship, Queen Anne’s Revenge, was found off the coast of Beaufort, where it had been hiding for more than 270 years. While the dives did not uncover much treasure, archaeologists estimate the wreckage holds up to 750,000 artifacts, some of which are displayed at Beaufort’s North Carolina Maritime Museum.

Blackbeard is a primary local industry. Ocracoke Island, a favored Blackbeard anchorage, was where he met his fate at the hands of what he mocked as a rabble of “cowardly puppies.” Bath has the legendary ball of light, presumed to be Blackbeard’s ghostly severed head.

So why watch Johnny Depp impersonate a pirate at the multiplex when you can check out the history of this famous scoundrel? Like we said, this old, dead, head-free pirate is a godsend for small business…

Tar is my name. Fossils are my fame

If you’re stuck for a scientific sojourn in Southern California, head for the pits. Since long before there was a Los Angeles, the La Brea Tar Pits have been an oozing, 3-D flypaper for animals, now with that all-too-trendy urban accent. Asphalt, we learn, is not just good for roads, but also for trapping live animals and preserving their fossils. Since their first description in a scientific publication in 1875, the pits have produced prodigious prizes for paleontology. The onsite Page Museum houses more than 650 species of plants and animals, all removed from the black goo, and dating back 11,000 to 50,000 years.

The tar pits were a graveyard for thousands of carnivores, including the dire wolf, coyote and saber-toothed cat, and a smaller number of herbivores, including mammoth and bison. In an effort to transcend the “heroic” era of paleontology and flesh out (if we can put it that way) a comprehensive picture of life in the era of ice, researchers have recently shifted their focus to fossils of plants and smaller animals, including millipedes, 31 species of mollusks, and 25 species of beetles.

Listen hard: Hear the galaxies?

Love big? Dig distant, mysterious and unfathomably old? At the Very Large Array, in western New Mexico, you can gawk at 27 giant antennas used by astronomers to “listen” to radio signals from the universe. When you’re done rubber-necking the hardware, check out exhibits at the visitor center.

Then climb an observation tower to get another view of the world’s premier radio telescope zoo. Notice how every single antenna has silently and inexorably changed its orientation, and is now pointing to another invisible spot in the heavens? You are looking at visual proof of our planet’s normally insensible rotation.

It takes a lot of work, and some hefty equipment, to pry loose the secrets of the universe, and here, the scale of the operation is written across the desert. Since 1980, the VLA has, alone or in tandem with other telescopes, been collecting the astrophysical evidence for the formation and destruction of stars and galaxies. The new “enhanced VLA” can “hear” three times as many radio bandwidths as the VLA and is 10 times more sensitive. How sensitive is that? They say it could hear a cellphone calling from Jupiter…

Go under cover in the capital city

Explore life under cover (and the technology that allows a spy to hide in plain sight) at the International Spy Museum, the only public museum of its kind in the United States. With the largest public collection of international espionage artifacts, the museum provides a unique global perspective of this covert profession — said to be the second oldest — and how it has shaped the past and present.

Before you start your mission, you are challenged to adopt a secret identity. As you snoop about, you’ll discover the Secret History of History, which highlights the influence of spies through the ages; gadgets and stories of espionage during the American Civil War, World War II, and Cold War; and a gallery of spy technology. You can even see if you have what it takes to be an agent in the Operation Spy interactive experience, in which you must find a missing nuclear trigger before it ends up in the wrong hands. Just don’t blow your cover!

Visit the “Boneyard”

Warplanes go to the desert to die, and there, for a fee, you can tour thousands of mothballed fighters, bombers and helicopters at the 309th Aerospace Maintenance and Regeneration Center. Bus tours run from the Pima Air and Space Museum, on the outskirts of Tucson, Ariz. With more than 4,200 planes, the “boneyard” is the ultimate in aerial combat nostalgia.

Some of these planes will be scrapped, others may be sold or salvaged for parts, or pressed back into service during future wars. Seldom celebrated, but perhaps more important from a technological point of view, the site also stores 350,000 tools used to make these machines, including, we presume, the one-of-a-kind tools and dies used to shape jet engines, wings and fuselages.

Ogling killing machines may seem macabre, but then, if you are a U.S. taxpayer, you’ve already paid for this stuff… might as well check it out, and witness how the technology of aerial warfare has changed over the decades!

Edison’s Garden of Invention

In 1887, after he had patented the first practical electric light bulb, mega-inventor Thomas Edison invented an inventor’s playground in West Orange, N.J., just outside Manhattan. Edison stocked the lab with every resource needed to crank out movie cameras and projectors, teletypes, recording and playback devices, batteries and countless other electric gadgets for the fast-modernizing nation.

With labs focusing on chemistry and physics, and with shops devoted to woodworking and metal-working, Edison could concentrate on his strong points: cranking out ideas and masterminding publicity stunts that helped ensure his commercial success. During World War I, 10,000 people cranked out electrical devices for the military at the factories clustered around the lab. Edison worked at the West Orange lab until his death in 1931.

Think of Edison as primarily an inventor? Then you have to wonder how his name wound up on the companies selling electricity to New York and Chicago. God may have made the Garden of Eden, but Thomas Edison made the garden of invention in north Jersey, and it awaits your visit.

– David J. Tenenbaum & Jenny Seifert

On May 4, scientists announced success after a 50-year quest to measure two key consequences of Einstein’s theory of general relativity. The most perfectly round objects ever created by human hand, spinning aboard a spaceship launched in 2004, have detected infinitesimal disturbances in spacetime, the invisible fourth dimension of the universe:

To The Why Files, frame-dragging means that space is no longer flat, or even just warped. It is also twisted. And as a matter of principle, The Why Files likes twisted.

These consequences of predictions made in the early 20th century by history’s archetypal theoretical physicist are yet more proof that Einstein had it right, and are the latest chapters in history’s most compelling scientific detective story; which substantiated the highly theoretical speculation of a brilliant scientist through nuts-and-bolts observations of the universe.

Courtesy Eric Zuelow, University of New England

Is this tyke being “frame-dragged” in accordance with Einstein’s general theory of relativity, or is he just playing in a park in Kenilworth, England?

1905: Relatively special

In 1905, the same year he finished his Ph.D. thesis, Einstein published several amazing insights, including papers on Brownian motion and the photoelectric effect (the latter won Einstein his sole Nobel Prize). One of those papers proposed a theory of “special relativity” that said that the speed of light is fixed and independent of the observer’s motion. The 1887 Michelson-Morley experiment convinced Einstein that there was no ether (the supposed physical background that allowed light to move), and that the laws of physics were the same in reference frames moving with a constant velocity relative to each other.

Common sense says that a ball thrown from a moving car will move faster than one thrown by a person standing still – and still faster for someone in another car driving towards it. Common sense, Einstein proved, does not always apply. The speed of light does not depend on whether the light source is mounted on a Stanley Steamer, a space ship or a water tower. The speed of light is constant. And it doesn’t matter whence you observe it. Light speed is light speed. End of story.

Image: FL0

Using a device like this, Michelson and Morley found that light had the same velocity under different circumstances; a key stimulus to Einstein’s thoughts while working on special relativity.

1916: General relativity

Einstein’s theory of “general” relativity described how gravity affects space and time. Following his habit, Einstein started a thought experiment — a series of “what-if” questions – related to gravity: “If I were falling through space, I would not feel gravity.” Therefore, the laws of physics did not require gravity in every situation. But since the laws of physics must apply everywhere, then gravity must result from something else, which Einstein concluded was the fabric of spacetime.

The classic explanation for spacetime is this: gravity results when the curved fabric of spacetime causes a massive object (a bowling ball or a galaxy) to distort space-time, causing other objects to fall toward the “valley” it has created in spacetime. To us, this looks like gravity, but to Einstein, it’s more a matter of geometry.

1906: Working on the proof

One year after Einstein published special relativity, scientists got some support for the theory, says Richard Staley, an associate professor of the history of science at the University of Wisconsin-Madison. Einstein and others had predicted, for different reasons, that certain fast-moving electrons would gain mass. German physicist Walter Kaufmann did some experiments, and interpreted his results as proof that the mass gain was due to a competing theory rather than relativity, but “the tests were not accurate enough to make a decisive choice between the different theories,” Staley says.

1919: Sun’s gravity bends light

The first confirmation of general relativity appeared after a highly publicized journey by British astronomer Arthur Eddington. During a total solar eclipse, Eddington observed stars that were almost directly behind the sun. As predicted by general relativity, their starlight was bent by the sun’s gravity.

Gravity, counter to intuition, could bend light, and Eddington, no dunce, became an ardent popularizer of relativity.

Although we may look back on Einstein as an oddball with a zany haircut who stuck out his tongue and rode a bike, he was a serious man who thought about politics as well as physics. Living in Germany during World War I, he was an outspoken pacifist who organized scientists against militarism. “Einstein thought we needed to think across national borders and tried to start a book project to include contributions from people from neutral and enemy countries,” Staley notes. “Most of his colleagues said it was a great idea, but would be counterproductive. They refused to participate, so it did not happen.”

Even before his fame got a boost by the 1919 confirmation of relativity, Einstein was willing to “take stances counter to others,” Staley says. “He was cautioned about going public, but when the war was finished, he decided he’d been right. Even though physics does not give you a particular insight into politics, it was clear that nobody had better insights, so he might as well make his views public.”

1974: Neutron stars and gravity waves

By the 1920s and ’30s, relativity was enshrined as a foundation of physics, but the proofs rolled on. In 1974, researchers found that a pair of neutron stars — phenomenally dense objects formed after regular stars collapse — was losing energy. Neutron stars emit extremely regular radio pulses, and the slowing of the pulses was interpreted to mean they were losing energy through the gravitational waves that general relativity predicts. The discovery won the 1993 Nobel Prize for physics.

Detecting gravity waves remains the object of an expensive, long-term scientific quest.

1979: One weighty lens

In 1936, three years after Einstein emigrated to the United States to escape the Nazis, he predicted that immense gravitation would bend light rather like a lens. Contemporary telescopes were unable to find such a “gravitational lens,” but in 1979, astronomers noticed two surprisingly similar images of a distant quasar and concluded that they were looking at a double image of one giant light source, split in two by a cluster of galaxies along the sight path to Earth.

“As usual, Einstein was ahead of the curve,” Harvard historian of science Gerald Holton told The Why Files in 1997. In 2006, a single quasar appeared in five individual images, again due to the gravity of an intervening cluster of galaxies.

Apparently a trillion stars, more or less, will do strange things…

1997: Neutron stars and frame-dragging

Although the 2011 report from Gravity Probe B was the first to identify “frame-dragging” of spacetime due to Earth’s mass, in 1997, scientists reported that rotating black holes and neutron stars were frame-dragging. The study, by Wei Cui at Massachusetts Institute of Technology, found that the gravity of a black hole spinning several thousand of times per second was distorting spacetime into a funnel shape. “It’s a very abstract thing,” Cui told us.

Black holes are extraordinarily dense points in space with a super-intense gravity that even traps light. Their presence can be deduced from a shower of X-rays produced as matter falls into the hole.

Scientists have long accepted that massive objects distort spacetime much as a bowling ball would distort a web of fabric that supports it. But frame-dragging means a rotating mass has some “sticky” quality that drags spacetime, and frame-dragging was more proof that Einstein was right, Cui said. “These are all results of his theory of general relativity, which described gravity.” In other words, gravity becomes a property of spacetime. “You can take all the facts of gravity and explain them with a certain geometry of spacetime.”

1995: The ultimate chill-out

Back in 1925, when “automobile” meant model A, and “president” meant “Silent Cal” Coolidge, Einstein predicted that a strange phase of matter would exist near absolute zero, a frosty -273°C. Expanding upon the calculations of Indian physicist Satyendra Nath Bose, Einstein calculated that atoms would enter a unified quantum-mechanical state near the coldest possible temperature.

The atoms would become a drill sergeant’s dream — identical in mind and body.

What was dubbed the “Bose-Einstein condensate” would also be a new phase of matter. Since only four phases exist in the universe — gas, liquid, solid and plasma — discovering another phase would pump up a resume.
In 1995, Carl Wieman, a professor of physics at the University of Colorado, and colleague Eric Cornell fulfilled Einstein’s prediction by creating this bizarre phase of matter at just 200-billionths of a degree Celsius above absolute zero. As Wieman told us in 1997, “We wanted to see if real atoms could ever match the ideal system that Einstein was considering, and they did match — really quite nicely.”

Quantum mechanics says that atoms can exist in certain energy states, but not in between. A group of atoms occupies numerous energy states, washing out the quantum-mechanical effects, but in a Bose-Einstein condensate, Wieman said, “You have a bunch of atoms in a single quantum state, obeying the laws of quantum mechanics as a whole. Traditionally, to see a quantum state, you had to look inside a single atom. Now we can look at millions of atoms.”

2011: Sweet success smiles on Gravity Probe B

The insights of the former Swiss patent clerk are impossible to exaggerate, but it took a lot of technical sophistication and ingenuity to detect disturbances in spacetime in the vicinity of Earth. That was the goal of Gravity Probe B.

Francis Everitt, a Stanford University physicist who has devoted his career to sailing Gravity Probe B across technological and financial shoals, compares the “dragging” of spacetime to a giant pot of honey. “As the planet rotated its axis and orbited the Sun, the honey around it would warp and swirl, and it’s the same with space and time.”

Save for the effects of gravity and relativity, the high-tech gyroscopes aboard the spaceship should point forever in one direction. Instead, gravity changes their orientation in subtle but measurable ways.

The rotors in those gyroscopes are the most precise spheres ever manufactured, which is astonishing if you consider that they were measured with “micro-inches” rather than microns.

It is not necessary  to offer a practical justification for a proof of relativity – simply explaining the universe is ample. But Gary Shiu, a professor of physics at the University of Wisconsin-Madison, notes that the ultra-precise equipment crafted for the gravity probe helped improve global positioning systems and the gizmos used to map the microwave background radiation that was created shortly after the Big Bang and still pervades the cosmos. “These technologies have already been developed, the spinoff already proven,” Shiu says.

Although some of the previous proofs of general relativity could conceivably be explained with alternate theories, Shiu says, “The frame-dragging detected in Gravity Probe B provides yet another independent test that any alternative to Einstein’s general relativity would have to meet.”

A man apart

A theory must explain the working of some aspect of nature, and it must be tested, generally by trying to disprove its predictions. Does your theory say gravity is an attraction between any two objects? Then, if you can find objects that fail to attract, you need to revise or reject your theory.

After a century of confirmation of Einstein, the obvious remaining question concerns scientific creativity rather than physics: What was Einstein’s secret? “He was very persistent, was the prototypical scientist,” says Shiu, who helped organize an upcoming conference on Cosmology since Einstein. “When he wanted to solve a problem, he could take 10 or 20 years. We cannot figure out the answer in a few months or years, we need to do whatever it takes to solve the problem.”

Kip Thorne, a California Institute of Technology physicist, told us in 1997 that he attributed Einstein’s deep insight to his “conviction that the universe loves simplicity and beauty… His willingness to be guided by this conviction, even if it meant destroying the foundations of Newtonian physics, led him, with a clarity of thought that others could not match, to his new description of space and time. … All new laws that have been successful in describing the real universe have turned out to obey Einstein’s principle of relativity.”

Indeed, Thorne called relativity a kind of super-law that “must be obeyed by all laws of physics, no matter whether they are laws governing electricity and magnetism, or atoms and molecules, or steam engines and sports cars.”

Gerald Holton, a physicist and historian of science at Harvard University, pointed to several characteristics that helped Einstein ^{1 2} excel:

Beyond a unique ability to peer inside the universe, Holton says Einstein also wrote about his philosophy and technique. “This man allowed himself to be more public and frank, and in particular about his scientific method, which is very much the method still used by other physicists.”

Yet for all his brilliance, Einstein failed to find the holy Grail of physics –a “grand unified theory” to explain all four physical forces. Electromagnetism and the strong and weak nuclear forces are explained by a single theory called the “standard model,” but to this day, gravitation stands stubbornly apart.

Summing up? Einstein

Einstein’s revolutionary theories grew from his philosophy of nature and insistence that physical laws must be true on Earth, space ships and stars, combined with a phenomenal intuition for nature and enough self-confidence to rewrite Newton’s laws of gravitation and motion. Einstein interpreted experiments from the 1880s, which suggested that the speed of light was independent of the observer’s motion, as meaning that the speed of light is constant throughout the universe. He then proposed that mass would affect light and spacetime, which is the backdrop for all events, atomic, human, cosmic and comic.

Still, everybody makes mistakes. Einstein denied the existence of black holes and loathed the role of chance in quantum theory, saying “God does not play dice with the universe.” He also cooked up a “cosmological constant” because his theories implied that the universe was changing size, which he considered too weird to be true.

When astronomer Edwin Hubble proved that the universe was expanding, Einstein called the cosmo constant “the greatest blunder of his life.” And yet recent discoveries indicating that the universe is, for unknown reasons, expanding ever faster could mean that his “greatest blunder” was not that far off…

Although Newtonian physics still describes what we see every day, more than a century after the young patent clerk brutally shouldered Newton aside, there’s no question Einstein grasped the big picture. And that returns us to this simple question: “How did he do the things he did?”

“Einstein was typically working between several different theoretical approaches,” says Staley, the science historian. “He was looking for places in which the best laws we currently have fail or don’t provide clear guidance, and then was trying to use those critical gaps to provide new insight into connections between different areas. People often think he thought outside the box. I think he thought across several boxes, and saw ways to link theory that others did not recognize. Although others were also looking at the limits of theory and trying to unify different areas, he did it better.”

For decades, scientists have thought that the pre-historic Antarctic climate was governed by events at the other end of the planet — in the Arctic. That’s because variations in solar radiation in the northern summer tracked nicely with the temperature record from sediment cores and ice cores taken on or around Antarctica.

Our record of temperatures in the deep south is carried in the ratios of oxygen and hydrogen isotopes (atoms with different masses) contained in ice cores. But Thomas Laepple, of the Alfred Wegener Institute for Polar and Marine Research in Germany, has just published an article maintaining that because the Antarctic ice cores did not accumulate at a steady pace, they have not been interpreted correctly.

Today, more snow (the source of ice), gathers in winter. Because that likely also happened in the past, ice cores from Antarctic tell us more about winter than summer, says Laepple.

And God created winter!

Photo 1: Hans Oerter, Alfred Wegener Institute, Germany, Photo 2: Eric Cravens, National Ice Core Lab

This 150,000-year-old piece of Antarctic ice is 10 centimeters in diameter, and was taken from a depth of 2,250 meters. After researchers clean, measure and catalog this core, it may be stored in a giant freezer like the one in the next image (rollover).

When Laepple and his colleagues factored in this seasonal effect, the level of sunlight in the southern hemisphere suddenly began to explain Antarctic temperatures. Although the orbital cycles still globally affect solar radiation, there was no longer a need to look at the other end of the Earth to explain rhythms in Antarctic temperatures.

The orbital cycles in question are named for Serbian engineer Milutin Milankovitch, who, about a century ago, sought to understand how three slow shifts in Earth’s orbit would affect the amount of sunshine in different regions, different seasons and years.

These orbital variations, which are influenced by gravity of the moon, sun, Jupiter and Saturn, are the basis of the “Milankovitch cycle:”

As scientists examined ocean sediments and then ice cores, the Milankovitch influence on solar radiation in the Northern hemisphere became the accepted explanation for the changing global climate. But when Laepple factored in the seasonal nature of Antarctic snowfall, he found that Milankovitch could explain the climate on the southern continent more directly. “I don’t question that the Milankovitch cycle has an influence on climate,” says Laepple, “but I question that its influence on the Antarctic is coming through the Artic.”

The adjustment was needed because more ice accumulates during winter and does not affect the overall climate record, Laepple says, “but it completely changes the recording of the signal stemming from the precession of the earth axis, which was the evidence for the remote North-South connection.”

Photo 1: Steven Profaizer, Photo 2: Sepp Kipfstuhl, Alfred Wegener Institute, Germany

Scientists use massive drills to uncover the stories about past climates told in ice cores (roll over for to see a core from a depth of 2,668 meters).

How would you explain it?

Climate is never simple, notes Richard Alley, a climate expert and professor of earth science at Penn State, who was not involved in the research. The Milankovitch cycle, he says, “shifts sunshine around on the planet, with more in some places and less in others, changing the length of seasons, the total sunshine during seasons … so it is not surprising that multiple hypotheses can be advanced to explain a given climate record. Ultimately, the mere fact of correlation is not the answer; we seek understanding of the physical linkages. … The new paper provides a clever new idea for a physical linkage, and I anticipate it will get people discussing and studying.”

Any new study concerning climate processes could get sucked into the political vortex enmiring global warming, so we asked if Laepple’s study of Antarctic conditions should lead us to question the widely-accepted theory that burning fossil fuels and changing land use have altered the climate.

Laepple reminded us that he’s studying changes that occur over periods of 10,000 years. He also insists that the new analysis “will not change the basic record of glacial and interglacial periods — the march of ice ages over the past million years. We are focusing on the precession cycle [the 21,000-year cycle affecting the location of Earth's axis], as this provides the evidence showing where and how the climate is affected by radiation changes, and might hold the key to the mechanism of slow climate change.”

Years ago, scientists began to revise their interpretation of Greenland ice to account for the seasonality in snowfall, Laepple says. “This new study is part of a long discussion. As we interpret the climate record, we have to focus more on how the climate signal gets recorded in the climate record.”

Talk about going to extremes: In 2004, an anonymous American man with ulcerative colitis chose to eat parasitic worms instead of having his diseased colon removed. He hoped that whipworms would provide a last-ditch biological balm for painful, bloody and frequent diarrhea, and more serious complications of colitis.

If his symptoms had not improved, you would not be reading about his sojourn through planet parasite. “It did work with this individual, he seemed to get better, not just once but twice,” says P’ng Loke, a parasite immunologist at New York University who studied the case.

Photo: Delorieux for Johann Gottfried Bremser

Imagine swallowing 2000 of these guys. You just might, if you were plagued with an inflammatory bowel disease.

In the same year that Mr. A swallowed those worm eggs, two other biological treatments gained Food and Drug Administration blessing as “medical devices”: leeches for removing excess blood after surgery, and maggots for cleaning difficult wounds.

Live organisms once played a bigger role in medicine, observes Ronald Sherman, a California doctor and maggot maven. “Before we had a good method for controlling syphilis, the bacterium was killed by inducing a fever, and one of the best methods was through malaria, carried by mosquitoes.”

Ready for some greatest hits from the ancient-but-modern realm of medicinal vermin?

Wondrous whipworms

Ulcerative colitis is a chronic bowel disease that afflicts up to one American in a thousand, apparently caused by some combination of inflammation and heredity. There is no cure. To prevent holes in the colon and other nasty outcomes, the bowel is often removed — a treatment that is also used for Crohn’s, the other major inflammatory bowel disease.

Photo: Uma Mahadevan, UCSF

Mr. Anonymous’s colon has a heavy infestation with whipworms, which are damaging the intestinal walls. Could that bleeding be a good thing?

In 2003, Mr. Anonymous was diagnosed with ulcerative colitis, and in 2004, he went to Thailand and ate 500 eggs of Trichuris trichiura, a parasitic helminth worm, and then 1,000 more.

The symptoms abated, and when they returned in 2008, Mr. A, who’s now 35, slurped 2,000 more whipworm eggs, and again his symptoms receded.

There is some support for the idea that parasitic worms can help with ulcerative colitis. Whipworms infest almost a billion people around the world, and colitis is scarce in infected regions. Animal tests, and one human trial¹ suggest that parasitic worms can help with ulcerative colitis.

This story of salvation courtesy of planet parasite might be dismissed as another tall tale told over a tall goblet of organic wheat-grass at the Health-4-All-Spa, except that Mr. A came under the scrutiny of medical experts² eager to explore the effect of parasites on one ulcerated colon.

Although eating worm eggs twice reduced the symptoms, one person does not constitute scientific proof, says Loke, a parasite expert. “The question is whether it would work for everyone, and for whom it would do more harm than good; that’s what we worry about.”

Image: Kimberley Evason, UCSF

Stained Trichuris trichiura eggs inside a worm from the ulcerative colitis patient who infected himself with these whipworms.

Whipped into shape?

The study did pinpoint a mechanism of help, and surprisingly, it was not, as expected, via a dampening the immune system. “When we analyzed this patient, we started thinking that the protection may be more related to restoring mucus production,” Loke says.

Mucus protects the intestinal lining from bacteria and other dangers, and Loke and his colleagues think the worms accelerated activity in genes involved in producing mucus, through a stimulating chemical called IL 22.

A second benefit probably came from faster growth of cells lining the intestine, Loke added. “We know from mouse studies of Trichuris that the mechanism of expelling the parasite from the gut involves a combination of turning over epithelial cells so worms will get sloughed off, and an increase in mucus production.”

Immunology still matters, he says, but it may be that the worms are triggering a protective immune response rather than immune suppression.

Before worms could be considered a treatment for ulcerative colitis, “we hope to understand the mechanism a bit better,” says Loke. “In the ideal situation, we’d like to activate this response without using the worms themselves.”

Amen.

Photo: Professor David B. Fankhauser, University of Cincinnati Clermont College.

Goblet cells (arrow) in the intestinal lining create protective mucus. Increased mucus production could explain how whipworms treat ulcerative colitis.

Worms v. asthma

There’s been some hope that regulating the immune system could help with asthma, but the improvements in patients in a clinical trial³ of hookworms were, disappointingly, not statistically significant.

But 13 of the 16 patients who swallowed hookworms decided not to get de-wormed afterwards, which suggests some perceived benefit, admits study author John Britton, in the division of epidemiology and public health at the University of Nottingham (United Kingdom). “We weren’t able to measure anything objective; hence the implication that larger, longer (and simpler) trials are needed.”

If you are tempted by do-it-yourself worm treatment for asthma, Britton has simple advice: “Don’t. There’s no evidence that it works.”

Both the benefits and the risk remain to be documented, says Loke, who tracked Mr. Anonymous, “and we don’t understand that fully. Worms can cause symptoms of colitis” and in the case of Mr. A, “are causing damage to the gut. But we think the gut is activating a healing response against the worms, and one benefit of that is the side effect of helping colitis.”

Marvelous maggots

While people have long used live organisms for medical purposes, many trace the scientific foundations of maggot therapy to World War I, when surgeon William Baer observed that maggot-infested wounds were often the cleanest and quickest to heal.

Photo: Alvesgaspar

Baby animals usually are cuter than the adults, but nobody told the green bottle fly!

In 1929, Baer reported complete success after treating 21 bone infections with maggots, and fly larvae quickly gained acceptance for wound treatment. But when antibiotics became widespread in the 1940s, healing became simply a matter of sprinkling a magic powder, and maggots were forgotten.

With diabetes becoming epidemic, and with so many bacteria immune to antibiotics, maggot use is again on the upswing. One key use is treating foot ulcers: slow-healing sores that affect about 15 percent of people with diabetes, and force 70,000 amputations each year in the United States.

Since Baer’s time, the common green-bottle fly, Phaenicia sericata, has been the preferred medical maggot, because it devours dead tissue, but not living flesh. Flies must be sterilized before use, and because the eggs quickly hatch into larvae (maggots), air-shipment is necessary, says Ronald Sherman, laboratory director of maggot-maker Monarch Labs.

The healing never stops

Sherman says he became interested in blending entomology and medicine when he read about Baer during medical school. “I was always interested in medical entomology, the intersection of health and insects, but usually that was in the context of insects that cause disease. I was also interested in the beneficial uses of insects.”

As investigations in maggot therapy started to ramp up the 1980s, he recalls a “huge wave of resistance [that] was not all due to revulsion” at the thought of hosting insects.

Part of the problem was resistance to change, he says, especially “When that change is associated with these negative, emotional connotations: death, flies, an unhygienic environment.”

Some resistance, he says, came from doctors “who saw that patients were lining up for [maggot] treatment. People … were canceling amputation surgeries … just to give maggot therapy a try!” According to Sherman⁷, some studies show that maggots can “salvage” 40 to 50 percent of limbs and digits scheduled for amputation.

One study⁸ found that although 43 percent of patients had flies escaping from their wounds, and 19 percent eventually needed amputation, 89 percent would use maggots again.

Courtesy Ronald Sherman

A bottle of chemically sterilized maggots costs about $100, plus shipping. Because the adult flies can be infectious, they must be restrained with cheesecloth or a special-purpose dressing.

Flies on trial

Other studies are less definitive. For example, in a randomized trial⁹ of wounds published in 2009, larvae-infested leg wounds were more painful, and while maggots were better at cleaning, they did not hasten healing or reduce bacterial infections.

A review¹⁰ of randomized treatments for diabetic foot ulcers found that “one small trial suggested that larvae resulted in a more than 50 percent reduction in wound area compared with hydrogel.” (Hydrogels are new dressings that keep wounds moist.)

Why only “one small trial” for the common diabetic foot ulcers? Because the gold standard for selecting therapies requires that neither doctor nor patient know which treatment was used — but this “double-blind” is doubly difficult when the medical device is a mess of growing flies!

Sherman, who is a maggot entrepreneur as well as medical doctor, says maggot therapy ought no longer be considered a last resort. “Most clinicians come to it either because their patients, or they themselves, are at a dead end. Facing amputation, they’ve run out of options. Once they see what maggots can do, and recognize how simple, inexpensive, and relatively safe they are, they recognize that they don’t have to wait so long, and in the future will think about maggot therapy … before the wound has progressed, before the infection has progressed.”

Image: Rsabbatini

Leeching was standard practice until the mid-1800s. Leech saliva contains anesthetics, which could also explain why this lady is so cool, calm and collected with her slithery pals!

Maggot therapy is occurring “throughout the world,” Sherman says. “Twenty-four labs are producing medical grade maggots and providing them in 40 countries. In the United States alone, about 2,000 centers are regularly using maggot therapy. The treatments are included in textbooks, review articles on wound care and conferences.”

Leapin’ Leeches!

Leeches — bloodsucking aquatic worms — have been a part of medicine for at least 2,000 years. The Encyclopedia Britannica tells us that “Throughout most of Western history, leeching-or leechcraft-became such a common practice that a physician was commonly referred to as a ‘leech.’”

Modern-day “leeches” use leeches to drain excess blood after surgery. “The classic use is when a finger is reattached surgically,” says Kosta Mumcuoglu, a parasitologist at Hebrew University in Jerusalem. “Even if the surgeon succeeds nicely in reattaching the arteries, they often have problems with the veins, so blood can enter the finger but not return to the body. Then it’s a short time until the blood in the finger coagulates and the patient loses the finger.”

Surgeons may try to improve circulation with further surgery or anti-coagulants like heparin, says Mumcuoglu, president of the International Biotherapy Society. But if circulation is still stuck, “The skin may start to turn brown or violet, and any time now, the finger is going to be lost.”

Courtesy Kosta Mumcuoglu, Hebrew University¹¹

After finger-reattachment surgery, leeches excess blood that would otherwise clot and kill the finger. Those white objects are holding the surgery tight. Children whose fingers have been caught in doors are major beneficiaries of this surgery, but snowblowers can also amputate fingers.

Evolution plays two contrasting roles in our story: To avoid bleeding to death, mammals have evolved a powerful “coagulation cascade” that clots blood outside blood vessels. Because clotting could be deadly to leeches, they, like their bloodsucking brethren the ticks, mosquitoes and vampire bats, have evolved anti-coagulants.

One chemical in leech saliva, for example, blocks thrombin, which helps platelets clump to start a blood clot.

Not only do leeches produce prodigious amounts of clot-blockers, but they also have chemicals that relax blood vessels, which contributes to their utility in surgery. In 2004, leeches garnered FDA approval as a “medical device.”

The chemicals in leech saliva, aided by some manual clot removal, ensure that the skin around a surgery will bleed for hours or days after leeching. Even though the patient may need a blood transfusion, after a few days, “new blood vessels are growing in the area, and the circulation becomes normal, and we have a good feeling that we have saved the finger,” Mumcuoglu says.

Leeches also secrete anti-inflammatory compounds that are being tested against diseases linked to inflammation. In a randomized trial¹³ in Germany, four to six leeches, which attached for an average of 70 minutes, led to a significant decrease in pain of osteoarthritis of the knee after seven days, compared to the anti-inflammatory drug diclofenac. Leech treatment also significantly improved stiffness, function and general arthritis symptoms, for the entire 91-day study.

In 2008, the same researchers¹⁴ found that leeches. when compared to diclofenac, produced significant benefits in pain, mobility and quality of life for osteoarthritis of the thumb.

Solution: Outsourcing?

Still, leeches may never regain their former medical prominence. In London, in 1846, “at least tens of millions of leeches” were imported each year. A reservoir in Norwich, one author¹⁵ wrote, “might at least aid in supplying the quantity needed for our own consumption, instead of being almost entirely dependant, as we at present are, on a foreign supply.”

However, this last finding may be key to further progress, says Mark Siddall of the American Museum of Natural History, who led the group that identified three species. “This raises the tantalizing prospect of three times the number of anti-coagulants, and three times as many [other] biomedically important developments…”

Did we forget what parasitologists call the “Yuck! factor”? Do patients squirm at the thought of attaching primitive bloodsuckers to their wounds? Generally not, says Mumcuoglu. “We have less problem with leeches than with maggots. We explain, ‘This is your last chance, if you don’t want to lose the finger, we have to try this.’ … Nobody has rejected the treatment.”