Stem Cells: 5 Year Progress Report

1. Story map

2. Bio-bombshell

3. Latest news

4. All grown up

5. Making sense

Stem cell:
A cell that can change into other types.

Embryonic stem (ES) cell:
Cell from embryo, can become any cell type.

Adult stem cell: Stem cell from mature animal, often from bone marrow.

Differentiation: Process of becoming more specialized.

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BMP4 Initiates Human Embryonic Stem Cell... RH Xu et al, Nature Biotechnology, 2002; 20:1361-4.

Embryonic Stem Cell Lines Derived from Human Blastocysts, James A. Thomson et al, Science 1998 November 6; pp. 1145-11.

Flexible Arrangement: Neil Thiese and Ian Wilmut, Nature, Sept. 4, 2003.

Fusion of Bone-Marrow Derived Cells... Manuel Alvarez-Dolado et al, Nature Advance Online Publication, Oct. 12, 2003.

Homologous Recombination, TP Zwaka and J Thomson, Nature Biotechnology, 2003; 21:319-21..

Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell, Krause DS et al Cell. 2001 May 4;105(3):369-77.

Multiple Organ Engraftment by Bone-Marrow-Derived Myofibroblasts and Fibroblasts in Bone-Marrow-Transplanted Mice, Natalie C. Direkze et al, Stem Cells 2003;21:514-520.

Plastic Adult Stem Cells: Will They Graduate from the School of Hard Knocks, Malcolm Alison et al, Journal of Cell Science, pp. 599-603, 2003.

Rat Brains Respond to Embryonic Stem Cells, Gretchen Vogel, Science, Jan. 11, 2002.

Stem Cells and the Future of Regenerative Medicine: Committee on the Biological and Biomedical Applications of Stem Cell Research Board on Life Sciences National Research Council Board on Neuroscience and Behavioral Health Institute of Medicine, National Academy Press, 2002.

Stem Cells Not so Stealthy After All, Gretchen Vogel, Science, July 12, 2002.

Plasticity: Time for a Reappraisal, Constance Holden et al, Science, June 21, 2002.

Stemness Genes Still Elusive, Gretchen Vogel, Science, Oct. 17, 2003.

Stable Genetic Modification... M. Gropp et al, Molecular Therapy, 2003; 7: 281-7.

Juvenile diabetes

Parkinson's disease

The NIH stem cell portal.

Time magazine frames the debate.

The American Association for the Advancement of Science on the ethics and policy issues behind stem cell research.

The Stem Cell Research Foundation.

NOVA's stem cell special.

The University of Wisconsin-Madison offers a stem cell explainer and the WiCell Research Institute.

Transplant yourself over to our credits page.

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